RXRX

• Core Strategic Focus

  • Recursion's central organizational priority is harnessing full AI capabilities to develop improved medicines for patients consistently and with urgency, with a focus on building a repeatable, AI-driven drug discovery engine that delivers assets from early discovery through clinical development.

• Clinical Pipeline Progress

  • REC 1245, a potential first-in-class oncology program fully discovered via Recursion's AI platform, has demonstrated a well-tolerated safety profile with no dose-limiting toxicities observed to date, alongside an encouraging PK-PD profile. Additional data for this program is expected in the second half of 2026.
  • REC 4881, a candidate for familial adenomatous polyposis (FAP), a serious condition with no currently approved treatments, has already delivered strong proof of concept with meaningful and durable treatment impact. Recursion has initiated formal engagement with the FDA to discuss a potential registration pathway, with an update planned for the second half of 2026.
  • Rec4539, a best-in-class LSD1 inhibitor developed for small cell lung cancer and acute myeloid leukemia (AML), has dosed its first patient in a Phase 1 trial. This precision-designed molecule was engineered to address common class-limiting toxicities (such as thrombocytopenia) and offers potential improved safety and enhanced CNS penetration compared to existing agents in this class.

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