SYRE
Spyre Therapeutics, Inc.
NASDAQ · USHealthcareBiotechnology
$101.42+1.19%
Price as of Jul 20, 2026
SYRE ownership
Spyre Therapeutics, Inc. ownership & insider activity
Latest available institutional positioning and SEC Form 4 insider transactions, coalesced at the company entity level when listings share coverage.
Insider Activity
Sentiment
0/100
Buys (3m)
0
Sells (3m)
36
Net (3m)
-$421.4M
Insider trades by month Buys Sells
Feb
Mar
Apr
May
Jun
Jul
Context3-month price +36.4%Institutions accumulating (13F)
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| Jul 2, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Option | 7,500 | $14.50 |
| Jul 2, 2026 | Sloan Sheldonofficer: Chief Medical Officer | Sell | 6,500 | $87.52 |
| Jul 2, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 10,176 | $87.44 |
| Jul 2, 2026 | Sloan Sheldonofficer: Chief Medical Officer | Option | 8,334 | $27.46 |
| Jul 2, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 4,234 | $88.12 |
| Jul 2, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 590 | $88.91 |
| Jul 2, 2026 | Sloan Sheldonofficer: Chief Medical Officer | Sell | 1,834 | $88.34 |
| Jul 2, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 1,725 | $88.37 |
| Jul 2, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 5,775 | $87.55 |
| Jun 26, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 5,000 | $87.12 |
| Jun 26, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 10,000 | $87.14 |
| Jun 26, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Option | 15,000 | $14.50 |
| Jun 23, 2026 | HENDERSON MICHAEL THOMASdirector | Sell | 20,000 | $100.00 |
| Jun 23, 2026 | Fairmount Funds Management LLCdirector | Sell | 4,684,781 | $85.31 |
| Jun 3, 2026 | Sloan Sheldonofficer: Chief Medical Officer | Sell | 8,333 | $75.00 |
| Jun 3, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 3,100 | $72.06 |
| Jun 3, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 2,599 | $70.77 |
| Jun 3, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Sell | 1,801 | $69.75 |
| Jun 3, 2026 | Burrows Scott Lofficer: Chief Financial Officer | Option | 7,500 | $14.50 |
| Jun 3, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 3,294 | $71.38 |
| Jun 3, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 8,149 | $70.50 |
| Jun 3, 2026 | Turtle Camerondirector, officer: Chief Executive Officer | Sell | 3,557 | $69.40 |
| Jun 3, 2026 | Sloan Sheldonofficer: Chief Medical Officer | Option | 8,333 | $27.46 |
| May 29, 2026 | Milligan Sandradirector | Grant | 8,026 | $72.51 |
| May 29, 2026 | McKenna Mark C.director | Grant | 8,026 | $72.51 |
| May 29, 2026 | Stelzer Lauriedirector | Grant | 8,026 | $72.51 |
| May 29, 2026 | HENDERSON MICHAEL THOMASdirector | Grant | 8,026 | $72.51 |
| May 29, 2026 | Albers Jeffrey W.director | Grant | 8,026 | $72.51 |
| May 29, 2026 | Fairmount Funds Management LLCdirector | Grant | 8,026 | $72.51 |
| May 8, 2026 | HENDERSON MICHAEL THOMASdirector | Sell | 2,404 | $72.57 |
Source: SYRE SEC Form 4 filings, latest Jul 2, 2026. For informational purposes only — not investment advice.
Institutional activity (13F)
How institutions changed their SYRE positions over the last 6 months (SEC Form 13F).
Increased
144
New positions
89
Reduced
83
Sold out
32
Largest moves
| Institution | Action | Shares | Filed |
|---|---|---|---|
| FMR LLC | Increased | 11.8M | May 15, 2026 |
| FMR LLC | Increased | 11.6M | Feb 17, 2026 |
| BLACKROCK, INC. | Increased | 5.5M | Feb 12, 2026 |
| BLACKROCK, INC. | Reduced | 5.5M | May 13, 2026 |
| RTW INVESTMENTS, LP | Increased | 4.2M | Feb 17, 2026 |
| RTW INVESTMENTS, LP | Unchanged | 4.2M | May 15, 2026 |
| VANGUARD GROUP INC | Increased | 4.0M | Jan 29, 2026 |
| FAIRMOUNT FUNDS MANAGEMENT LLC | Unchanged | 4.0M | Feb 17, 2026 |
| FAIRMOUNT FUNDS MANAGEMENT LLC | Unchanged | 4.0M | May 15, 2026 |
| PERCEPTIVE ADVISORS LLC | Increased | 3.8M | May 29, 2026 |
| VR ADVISER, LLC | Increased | 3.7M | Feb 17, 2026 |
| VR ADVISER, LLC | Unchanged | 3.7M | May 15, 2026 |
| CAPITAL INTERNATIONAL INVESTORS | Increased | 3.5M | Feb 11, 2026 |
| PERCEPTIVE ADVISORS LLC | Increased | 3.1M | Feb 17, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | New Position | 3.1M | May 15, 2026 |
Source: SEC Form 13F filings. For informational purposes only — not investment advice.