STOK Stock: Insider Activity, Filings & Research

Stoke Therapeutics, Inc. (STOK) — Drillr’s hub for STOK insider activity, SEC filings, earnings signals and AI research. Over the trailing 3 months, STOK insiders filed 0 open-market buys and 29 sales (SEC Form 4).

Sentiment

0/100

Buys (3m)

Sells (3m)

Net (3m)

-$3.0M

Insider trades by month Buys Sells

Nov

Dec

Mar

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Jun

Context3-month price -14.4%Institutions accumulating (13F)

Date	Insider	Type	Shares	Price
Jun 3, 2026	Ticho Barryofficer: CHIEF MEDICAL OFFICER	Sell	1,795	$30.58
May 5, 2026	Ticho Barryofficer: CHIEF MEDICAL OFFICER	Sell	2,243	$32.79
Apr 7, 2026	Kahn Claredirector	Grant	30,782	$32.79
Apr 3, 2026	Ticho Barryofficer: CHIEF MEDICAL OFFICER	Sell	1,838	$32.66
Mar 24, 2026	Allan Jonathanofficer: GENERAL COUNSEL & CORP SEC	Sell	601	$34.41
Mar 24, 2026	Allan Jonathanofficer: GENERAL COUNSEL & CORP SEC	Sell	8,692	$33.64
Mar 19, 2026	Ticho Barryofficer: CHIEF MEDICAL OFFICER	Sell	6,100	$31.28
Mar 19, 2026	Ticho Barryofficer: CHIEF MEDICAL OFFICER	Sell	2,587	$33.38
Mar 19, 2026	Ticho Barryofficer: CHIEF MEDICAL OFFICER	Sell	1,461	$29.99
Mar 19, 2026	Allan Jonathanofficer: GENERAL COUNSEL & CORP SEC	Sell	334	$31.79
Mar 19, 2026	Ticho Barryofficer: CHIEF MEDICAL OFFICER	Sell	3,577	$32.74
Mar 19, 2026	Leggett Thomasofficer: Chief Financial Officer	Sell	37	$32.85
Mar 19, 2026	Hoitt Jasonofficer: Chief Patient Officer	Sell	748	$33.38
Mar 19, 2026	Ticho Barryofficer: CHIEF MEDICAL OFFICER	Option	1,365	$2.19
Mar 19, 2026	Hoitt Jasonofficer: Chief Patient Officer	Sell	1,033	$32.74

Source: STOK SEC Form 4 filings, latest Jun 3, 2026. For informational purposes only — not investment advice.

Overview

Stoke Therapeutics, Inc. (NASDAQ:STOK) is an early-stage biopharmaceutical company founded in 2014 and headquartered in Bedford, Massachusetts. Originally incorporated as ASOthera Pharmaceuticals, Inc., the company changed its name to Stoke Therapeutics in May 2016 and went public in June 2019. Stoke focuses on developing novel antisense oligonucleotide medicines to treat severe genetic diseases by addressing their underlying molecular causes rather than just managing symptoms.

Business

Stoke Therapeutics operates in the biotechnology sector, specifically developing antisense oligonucleotide (ASO) medicines for rare genetic diseases. ASOs are short DNA-like molecules that can bind to specific RNA sequences in cells to modify gene expression. Unlike traditional drugs that typically inhibit or block biological processes, Stoke's approach aims to increase the production of functional proteins that are deficient due to genetic mutations. The company's core innovation is its proprietary Targeted Augmentation of Nuclear Gene Output (TANGO) platform. This technology allows Stoke to design ASOs that precisely upregulate protein expression by targeting specific genetic mechanisms. When genetic diseases are caused by insufficient production of essential proteins, TANGO-designed ASOs can potentially restore normal protein levels and improve patient outcomes. Stoke's pipeline consists of two main programs. STK-001 is the company's lead clinical candidate, currently in Phase I/IIa clinical trials for treating Dravet syndrome, a severe form of genetic epilepsy that typically begins in infancy and causes frequent, prolonged seizures along with developmental delays. STK-002 remains in preclinical development for autosomal dominant optic atrophy, a genetic condition that causes progressive vision loss due to degeneration of the optic nerve. The company has also established a strategic partnership with Acadia Pharmaceuticals Inc. through a license and collaboration agreement focused on discovering, developing, and commercializing RNA-based medicines for severe and rare genetic neurodevelopmental diseases affecting the central nervous system.

Competitive moat

Stoke Therapeutics possesses a moderately strong but narrow moat built primarily around its proprietary TANGO platform technology and specialized expertise in ASO design for protein upregulation. The company's approach of increasing rather than decreasing protein expression differentiates it from most other ASO developers, creating a unique technical niche in the genetic medicine space. The company's intellectual property portfolio around TANGO technology provides some protection, though the biotechnology industry's rapid pace of innovation means that technological advantages can be relatively short-lived. Stoke's expertise in rare genetic diseases, particularly Dravet syndrome, has created valuable clinical relationships and regulatory knowledge that would be difficult for competitors to quickly replicate. However, the moat faces significant challenges. Large pharmaceutical companies with substantially greater resources could potentially develop competing approaches or acquire smaller biotechnology companies with similar technologies. Gene therapy companies represent a major competitive threat, as successful gene therapies could provide more durable treatment solutions than ASOs, which typically require repeated dosing. CRISPR and other gene editing technologies also pose long-term competitive risks by potentially offering permanent genetic corrections rather than ongoing protein augmentation. The company's moat is further limited by its early-stage development status and dependence on clinical trial success. Regulatory setbacks or clinical failures could quickly erode competitive advantages, while the small market sizes for rare genetic diseases limit the ultimate commercial opportunity even for successful programs.

Risks & safety

Stoke Therapeutics demonstrates a strong financial safety profile with substantial cash reserves and minimal debt obligations, though the company faces typical early-stage biotech risks around cash burn and development timeline uncertainties. • Cash position: $274.8 million in cash and short-term investments as of Q1 2025, providing significant runway for operations • Debt level: Minimal debt with debt-to-equity ratio of 0.0% in Q1 2025, indicating very low financial leverage risk • Current ratio: 8.41 in Q1 2025, showing strong short-term liquidity to meet obligations • Cash burn: Historical quarterly cash burn of $17-23 million suggests current cash could fund operations for several years • Valuation metrics: Trading at 0.85x P/E ratio in Q1 2025 following profitable quarter, though this reflects partnership milestone payments rather than sustainable earnings • Revenue volatility: Highly variable quarterly revenues ($4.8-158.6 million range) create uncertainty around sustainable cash generation • Clinical risk: Early-stage development programs carry substantial risk of failure, which could impact partnership values and future funding needs

Recent development

Based on the financial data trends, Stoke Therapeutics has experienced significant recent developments centered around partnership expansion and milestone achievements. The dramatic revenue increase to $158.6 million in Q1 2025, compared to quarterly revenues of $4.8-22.6 million throughout 2024, indicates major milestone payments or expanded collaboration agreements, likely related to the Acadia Pharmaceuticals partnership. The company has maintained steady clinical development progress with STK-001 advancing through Phase I/IIa trials for Dravet syndrome. The consistent cash burn rates of approximately $17-23 million per quarter throughout 2024 suggest disciplined spending on clinical operations and research activities. The company's ability to generate positive net income of $112.9 million in Q1 2025, following consistent losses in prior periods, reflects the successful achievement of significant partnership milestones. Strategic focus on central nervous system diseases has remained consistent, with the Acadia collaboration specifically targeting genetic neurodevelopmental diseases. This partnership appears to have evolved into a more substantial revenue generator, providing both near-term financial support and validation of Stoke's TANGO platform technology. The company has maintained its lean operational structure while building clinical expertise in rare genetic epilepsies and optic nerve disorders.

STOK company profile · for informational purposes only — not investment advice.

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