Septerna, Inc. (SEPN) Insider Trading
Over the last 3 months, SEPN insiders made 0 open-market buys and 7 sales, a net sale of -$624K (SEC Form 4). Over the last 6 months, 84 institutions increased and 60 reduced their position (13F).
Insider Activity
Sentiment
0/100
Buys (3m)
0
Sells (3m)
7
Net (3m)
-$623.7K
Insider trades by month Buys Sells
Nov
Feb
Mar
Apr
May
Jun
Context3-month price +6%Institutions accumulating (13F)
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| Jun 3, 2026 | Shaikhly Samiraofficer: Chief People Officer | Sell | 1,346 | $28.79 |
| Jun 3, 2026 | Shaikhly Samiraofficer: Chief People Officer | Sell | 1,700 | $27.78 |
| Jun 3, 2026 | Shaikhly Samiraofficer: Chief People Officer | Sell | 2,889 | $29.66 |
| Jun 3, 2026 | Shaikhly Samiraofficer: Chief People Officer | Option | 4,355 | $1.55 |
| Jun 3, 2026 | Shaikhly Samiraofficer: Chief People Officer | Option | 943 | $2.76 |
| Jun 3, 2026 | Shaikhly Samiraofficer: Chief People Officer | Option | 637 | $2.76 |
| May 28, 2026 | Shaikhly Samiraofficer: Chief People Officer | Option | 11,798 | $6.81 |
| May 28, 2026 | Shaikhly Samiraofficer: Chief People Officer | Sell | 11,798 | $30.06 |
| Apr 17, 2026 | Bhatt Elizabethofficer: President and COO | Option | 4,000 | $6.81 |
| Apr 17, 2026 | Bhatt Elizabethofficer: President and COO | Sell | 326 | $25.86 |
| Apr 17, 2026 | Bhatt Elizabethofficer: President and COO | Sell | 1,101 | $25.24 |
| Apr 17, 2026 | Bhatt Elizabethofficer: President and COO | Sell | 2,573 | $23.76 |
| Mar 4, 2026 | Shaikhly Samiraofficer: Chief People Officer | Option | 5,101 | $2.76 |
| Mar 4, 2026 | Shaikhly Samiraofficer: Chief People Officer | Option | 11,638 | $2.76 |
| Mar 4, 2026 | Shaikhly Samiraofficer: Chief People Officer | Option | 53,714 | $1.55 |
| Mar 4, 2026 | Shaikhly Samiraofficer: Chief People Officer | Sell | 4,090 | $27.51 |
| Mar 4, 2026 | Shaikhly Samiraofficer: Chief People Officer | Sell | 66,363 | $28.14 |
| Feb 20, 2026 | Bhatt Elizabethofficer: President and COO | Option | 4,000 | $6.81 |
| Feb 20, 2026 | Bhatt Elizabethofficer: President and COO | Sell | 2,200 | $28.46 |
| Feb 20, 2026 | Bhatt Elizabethofficer: President and COO | Sell | 1,800 | $29.58 |
| Feb 10, 2026 | Long Daniel D.officer: SVP, Drug Discovery | Grant | 80,000 | $25.41 |
| Feb 10, 2026 | Klein Uweofficer: SVP, Biological Sciences | Grant | 80,000 | $25.41 |
| Feb 10, 2026 | Shaikhly Samiraofficer: Chief People Officer | Grant | 80,000 | $25.41 |
| Feb 10, 2026 | Labrucherie Gil Mofficer: Chief Financial Officer | Grant | 125,000 | $25.41 |
| Feb 10, 2026 | Kim Jae B.officer: Chief Medical Officer | Grant | 125,000 | $25.41 |
| Feb 10, 2026 | Bhatt Elizabethofficer: President and COO | Grant | 155,000 | $25.41 |
| Feb 10, 2026 | Finer Jeffreydirector, officer: Chief Executive Officer | Grant | 400,000 | $25.41 |
| Feb 10, 2026 | Wilson Mark Andrewofficer: Chief Legal Officer | Grant | 165,000 | $25.41 |
| Nov 13, 2025 | Long Daniel D.officer: SVP, Drug Discovery | Sell | 3,501 | $18.06 |
| Sep 29, 2025 | Gottesdiener Keith Michaeldirector | Grant | 33,246 | $16.75 |
Source: SEPN SEC Form 4 filings, latest Jun 3, 2026. For informational purposes only — not investment advice.
Institutional activity (13F)
How institutions changed their SEPN positions over the last 6 months (SEC Form 13F).
Increased
84
New positions
64
Reduced
60
Sold out
30
Largest moves
| Institution | Action | Shares | Filed |
|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | Unchanged | 7.0M | May 15, 2026 |
| RA CAPITAL MANAGEMENT, L.P. | Unchanged | 7.0M | Feb 17, 2026 |
| TRV GP V, LLC | Unchanged | 6.2M | Feb 13, 2026 |
| TRV GP V, LLC | Unchanged | 6.2M | May 7, 2026 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | Reduced | 4.8M | Feb 17, 2026 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | Reduced | 4.4M | May 15, 2026 |
| TRV GP VI, LLC | Unchanged | 4.2M | Feb 13, 2026 |
| TRV GP VI, LLC | Unchanged | 4.2M | May 7, 2026 |
| SAMSARA BIOCAPITAL, LLC | Unchanged | 3.1M | Feb 17, 2026 |
| SAMSARA BIOCAPITAL, LLC | Unchanged | 3.1M | May 15, 2026 |
| GOLDMAN SACHS GROUP INC | Increased | 2.9M | May 15, 2026 |
| GOLDMAN SACHS GROUP INC | Increased | 2.7M | Mar 25, 2026 |
| SIREN, L.L.C. | Unchanged | 2.0M | May 14, 2026 |
| SIREN, L.L.C. | Reduced | 2.0M | Feb 13, 2026 |
| BLACKROCK, INC. | Increased | 1.8M | May 13, 2026 |
Source: SEC Form 13F filings. For informational purposes only — not investment advice.