Prelude Therapeutics Incorporated (PRLD) Insider Trading
Over the last 3 months, PRLD insiders made 6 open-market buys and 0 sales, a net purchase of $25.0M (SEC Form 4). Multiple insiders bought within days of each other (cluster buying). Over the last 6 months, 39 institutions increased and 28 reduced their position (13F).
Insider Activity
Sentiment
100/100
Buys (3m)
6
Sells (3m)
0
Net (3m)
$25.0M
Insiders buyingCluster buying
Insider trades by month Buys Sells
Apr
May
Dec
Jan
Mar
Apr
Context3-month price +30.2%Institutions accumulating (13F)
| Date | Insider | Type | Shares | Price |
|---|---|---|---|---|
| May 4, 2026 | Morris Charles Qofficer: Chief Medical Officer | Grant | 450,000 | $4.70 |
| Apr 23, 2026 | ORBIMED ADVISORS LLCdirector, 10 percent owner: | Buy | 1,126,126 | $4.44 |
| Apr 23, 2026 | ORBIMED ADVISORS LLCdirector, 10 percent owner: | Buy | 1,689,189 | $4.44 |
| Apr 23, 2026 | Bonita David Pdirector, 10 percent owner: | Buy | 1,126,126 | $4.44 |
| Apr 23, 2026 | Bonita David Pdirector, 10 percent owner: | Buy | 1,689,189 | $4.44 |
| Apr 22, 2026 | BAKER BROS. ADVISORS LPdirector, 10 percent owner: | Buy | 114,601 | $0.00 |
| Apr 22, 2026 | BAKER BROS. ADVISORS LPdirector, 10 percent owner: | Buy | 2,137,651 | $0.00 |
| Feb 5, 2026 | Scherle Peggyofficer: Chief Scientific Officer | Grant | 230,000 | $2.30 |
| Feb 5, 2026 | Vaddi Krishnadirector, officer: CEO | Grant | 837,000 | $2.30 |
| Feb 5, 2026 | Combs Andrewofficer: Chief Chemistry Officer | Grant | 230,000 | $2.30 |
| Feb 5, 2026 | Lim Bryant Davidofficer: CLO, CFO, Corp Sec. | Grant | 275,000 | $2.30 |
| Nov 7, 2025 | Sandor Victordirector | Grant | 121,285 | $1.39 |
| Oct 7, 2025 | Huang Janeofficer: President, CMO | Option | 9,375 | — |
| Oct 7, 2025 | Huang Janeofficer: President, CMO | Tax | 3,355 | $1.47 |
| Jul 8, 2025 | Huang Janeofficer: President, CMO | Option | 9,375 | — |
| Jul 8, 2025 | Huang Janeofficer: President, CMO | Tax | 3,355 | $0.79 |
| Jun 13, 2025 | Dier Mardidirector | Grant | 38,000 | $1.04 |
| Jun 13, 2025 | FRIEDMAN PAUL Adirector | Grant | 38,000 | $1.04 |
| Jun 13, 2025 | Bonita David Pdirector, 10 percent owner: | Grant | 38,000 | $1.04 |
| Jun 13, 2025 | Babler Martindirector | Grant | 38,000 | $1.04 |
| Jun 13, 2025 | Sandor Victordirector | Grant | 38,000 | $1.04 |
| Jun 13, 2025 | BAKER BROS. ADVISORS LPdirector, 10 percent owner: | Grant | 76,000 | $1.04 |
| Apr 7, 2025 | Huang Janeofficer: President, CMO | Tax | 3,355 | $0.68 |
| Apr 7, 2025 | Huang Janeofficer: President, CMO | Option | 9,375 | — |
| Mar 27, 2025 | Combs Andrewofficer: Chief Chemistry Officer | Buy | 100,000 | $0.69 |
| Mar 27, 2025 | Vaddi Krishnadirector, officer: CEO | Buy | 675,000 | $0.69 |
| Mar 24, 2025 | Vaddi Krishnadirector, officer: CEO | Buy | 5,416 | $0.73 |
| Mar 24, 2025 | Vaddi Krishnadirector, officer: CEO | Buy | 15,000 | $0.73 |
| Mar 18, 2025 | Vaddi Krishnadirector, officer: CEO | Buy | 29,999 | $0.75 |
| Mar 18, 2025 | Vaddi Krishnadirector, officer: CEO | Buy | 9,106 | $0.75 |
Source: PRLD SEC Form 4 filings, latest May 4, 2026. For informational purposes only — not investment advice.
Institutional activity (13F)
How institutions changed their PRLD positions over the last 6 months (SEC Form 13F).
Increased
39
New positions
20
Reduced
28
Sold out
13
Largest moves
| Institution | Action | Shares | Filed |
|---|---|---|---|
| ORBIMED ADVISORS LLC | Unchanged | 10.9M | May 15, 2026 |
| ORBIMED ADVISORS LLC | Unchanged | 10.9M | Feb 17, 2026 |
| BAKER BROS. ADVISORS LP | Unchanged | 10.1M | May 15, 2026 |
| BAKER BROS. ADVISORS LP | Unchanged | 10.1M | Feb 17, 2026 |
| BOXER CAPITAL MANAGEMENT, LLC | Increased | 2.1M | Feb 17, 2026 |
| KYNAM CAPITAL MANAGEMENT, LP | Increased | 1.6M | May 15, 2026 |
| VANGUARD GROUP INC | Increased | 1.4M | Jan 29, 2026 |
| VANGUARD CAPITAL MANAGEMENT LLC | New Position | 1.2M | May 15, 2026 |
| ECOR1 CAPITAL, LLC | New Position | 947K | May 15, 2026 |
| TWO SIGMA INVESTMENTS, LP | Increased | 924K | May 15, 2026 |
| KYNAM CAPITAL MANAGEMENT, LP | New Position | 789K | Feb 17, 2026 |
| TWO SIGMA INVESTMENTS, LP | Increased | 789K | Feb 17, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | 756K | Feb 17, 2026 |
| SPHERA FUNDS MANAGEMENT LTD. | Increased | 558K | May 15, 2026 |
| ACADIAN ASSET MANAGEMENT LLC | Reduced | 536K | Feb 10, 2026 |
Source: SEC Form 13F filings. For informational purposes only — not investment advice.