KALV Stock: Insider Activity, Filings & Research

KalVista Pharmaceuticals, Inc. (KALV) — Drillr’s hub for KALV insider activity, SEC filings, earnings signals and AI research. Over the trailing 3 months, KALV insiders filed 0 open-market buys and 23 sales (SEC Form 4).

Sentiment

0/100

Buys (3m)

Sells (3m)

Net (3m)

-$5.9M

Insider trades by month Buys Sells

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May

Context3-month price +64.6%Institutions accumulating (13F)

Date	Insider	Type	Shares	Price
May 29, 2026	Yea Christopherofficer: CHIEF DEVELOPMENT OFFICER	Sell	33,800	$26.78
May 29, 2026	Yea Christopherofficer: CHIEF DEVELOPMENT OFFICER	Option	33,800	$7.07
May 27, 2026	Yea Christopherofficer: CHIEF DEVELOPMENT OFFICER	Option	3,125	—
May 27, 2026	Sweeny Nicoleofficer: Chief Commercial Officer	Option	5,000	—
May 27, 2026	Yea Christopherofficer: CHIEF DEVELOPMENT OFFICER	Sell	1,966	$26.78
May 27, 2026	Sweeny Nicoleofficer: Chief Commercial Officer	Sell	1,489	$26.78
May 27, 2026	Audhya Paul K.officer: CHIEF MEDICAL OFFICER	Option	5,000	—
May 27, 2026	Audhya Paul K.officer: CHIEF MEDICAL OFFICER	Sell	2,239	$26.78
May 26, 2026	Piekos Brianofficer: Chief Financial Officer	Sell	1,489	$26.78
May 26, 2026	Audhya Paul K.officer: CHIEF MEDICAL OFFICER	Sell	2,685	$26.78
May 26, 2026	Audhya Paul K.officer: CHIEF MEDICAL OFFICER	Option	6,250	—
May 26, 2026	Yea Christopherofficer: CHIEF DEVELOPMENT OFFICER	Sell	2,358	$26.78
May 26, 2026	Palleiko Benjamin Ldirector, officer: CHIEF EXECUTIVE OFFICER	Option	23,250	—
May 26, 2026	Palleiko Benjamin Ldirector, officer: CHIEF EXECUTIVE OFFICER	Sell	10,926	$26.78
May 26, 2026	Yea Christopherofficer: CHIEF DEVELOPMENT OFFICER	Option	3,750	—

Source: KALV SEC Form 4 filings, latest May 29, 2026. For informational purposes only — not investment advice.

Overview

KalVista Pharmaceuticals, Inc. (NASDAQ:KALV) is a clinical-stage biopharmaceutical company founded in 2009 and headquartered in Cambridge, Massachusetts. The company went public in April 2015 and focuses on discovering, developing, and commercializing small molecule protease inhibitors for rare diseases with significant unmet medical needs. KalVista specializes in targeting the kallikrein-kinin system, a biological pathway involved in inflammation and vascular permeability, with particular emphasis on developing treatments for hereditary angioedema and diabetic macular edema.

Business

KalVista operates in the biotechnology sector, specifically focusing on developing small molecule protease inhibitors that target enzymes involved in disease processes. The company's primary therapeutic focus centers on the kallikrein-kinin system, a complex biological pathway that regulates blood pressure, inflammation, and blood vessel permeability. When this system becomes dysregulated, it can lead to serious medical conditions. The company's lead therapeutic areas include hereditary angioedema (HAE), a rare genetic disorder that causes episodes of severe swelling in various parts of the body including the face, throat, and extremities, and diabetic macular edema (DME), a complication of diabetes that causes fluid accumulation in the retina leading to vision problems. KalVista's product pipeline consists of several key candidates. Sebetralstat is their most advanced program, an oral plasma kallikrein inhibitor currently in Phase 3 clinical trials (KONFIDENT trial) as an on-demand treatment for HAE attacks. KVD001 is a plasma kallikrein inhibitor that completed Phase II trials for treating DME. KVD824 represents another oral candidate for HAE treatment, while their Factor XIIa inhibitor program remains in preclinical development, targeting an upstream enzyme in the same pathway that leads to HAE symptoms. As a clinical-stage company, KalVista currently generates minimal revenue and operates primarily as a research and development organization focused on advancing these therapeutic candidates through clinical trials toward potential regulatory approval and commercialization.

Competitive moat

KalVista's competitive moat appears moderate but fragile given the nature of biotech competition and their current development stage. The company's primary defensive position stems from their specialized expertise in kallikrein-kinin pathway inhibition and their specific small molecule approach to targeting plasma kallikrein. This scientific focus has allowed them to build a portfolio of related compounds targeting the same biological pathway from different angles. However, the moat faces significant challenges. The hereditary angioedema market already has established competitors including approved treatments from major pharmaceutical companies, which means KalVista will need to demonstrate superior efficacy, safety, or convenience to gain market share. Their oral delivery approach for sebetralstat could provide a competitive advantage over injectable alternatives, but this remains unproven until Phase 3 results are available. The company's intellectual property portfolio provides some protection, but biotech patents can be challenged and have finite terms. Additionally, the scientific understanding of the kallikrein-kinin system is advancing rapidly, meaning larger pharmaceutical companies with greater resources could develop competing approaches. The regulatory approval risk represents a fundamental threat to any moat, as clinical trial failures could eliminate the competitive position entirely. Once approved, the small patient populations in rare diseases could support pricing power, but also make the market attractive to well-funded competitors seeking to enter with potentially superior products.

Risks & safety

KalVista presents a moderate margin of safety from a balance sheet perspective but carries substantial execution risk typical of clinical-stage biotechnology companies. • Cash position: $167.3 million in cash and short-term investments as of Q3 2025, providing reasonable runway for operations • Burn rate: Quarterly cash burn of approximately $33-40 million based on recent operating cash flows, suggesting roughly 4-5 quarters of funding at current spending levels • Debt levels: Very low debt-to-equity ratio of 0.04, indicating minimal financial leverage risk • Liquidity: Strong current ratio of 10.4 and quick ratio of 10.4, demonstrating excellent short-term liquidity • Solvency risk: Low near-term bankruptcy risk given strong balance sheet, but will need additional financing within 12-18 months • Valuation metrics: Trading at 3.2x book value and negative earnings multiples due to losses, making traditional valuation difficult • Enterprise value: Negative EV/EBITDA ratios due to losses, indicating speculative valuation territory • Other considerations: Primary risk stems from clinical trial outcomes rather than financial distress; strong balance sheet provides buffer for potential setbacks but cannot eliminate binary nature of drug development risk.

Recent development

Based on the available financial data, KalVista has been advancing its clinical pipeline with sebetralstat as the primary focus, having initiated the Phase 3 KONFIDENT trial for hereditary angioedema treatment. This represents a significant milestone as the company transitions from Phase 2 to late-stage development, bringing them closer to potential regulatory approval and commercialization. The company has maintained a disciplined approach to cash management while funding multiple development programs. Their cash position improved significantly from $31.8 million in Q1 2025 to $167.3 million in Q3 2025, indicating successful fundraising activities that will support continued clinical operations. This capital infusion provides the financial foundation needed to complete the Phase 3 trial and advance other pipeline candidates. KalVista has continued developing their oral delivery platform for kallikrein inhibitors, which could provide a competitive advantage in the HAE market where many existing treatments require injection. The company's focus on building a portfolio of related compounds targeting different aspects of the kallikrein-kinin pathway demonstrates a strategic approach to maximizing their scientific expertise across multiple therapeutic applications. The progression of KVD824 as another oral HAE candidate and the advancement of their Factor XIIa inhibitor program through preclinical development shows the company's commitment to building a comprehensive pipeline rather than relying solely on sebetralstat's success.

KALV company profile · for informational purposes only — not investment advice.

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