Ionis Pharmaceuticals, Inc. (IONS) Insider Trading

Over the last 3 months, IONS insiders made 0 open-market buys and 17 sales, a net sale of -$11.4M (SEC Form 4). Over the last 6 months, 374 institutions increased and 297 reduced their position (13F).

Insider Activity

Sentiment
0/100
Buys (3m)
0
Sells (3m)
17
Net (3m)
-$11.4M
Insider trades by month Buys Sells
Jan
Feb
Mar
Apr
May
Jun
Context3-month price -7.1%Institutions accumulating (13F)
DateInsiderTypeSharesPrice
Jun 3, 2026BERTHELSEN SPENCER RdirectorSell8,000$75.67
Jun 3, 2026BERTHELSEN SPENCER RdirectorOption8,000$24.42
May 15, 2026Monia Brett Pdirector, officer: Chief Executive OfficerSell1,316$78.01
May 15, 2026Monia Brett Pdirector, officer: Chief Executive OfficerOption3,220$32.60
May 15, 2026Monia Brett Pdirector, officer: Chief Executive OfficerOption1,316$32.60
May 15, 2026Monia Brett Pdirector, officer: Chief Executive OfficerSell3,220$78.68
May 6, 2026LOSCALZO JOSEPHdirectorOption10,321$41.08
May 6, 2026LOSCALZO JOSEPHdirectorOption12,000$40.05
May 6, 2026LOSCALZO JOSEPHdirectorOption16,000$42.88
May 6, 2026LOSCALZO JOSEPHdirectorSell17,781$75.58
May 6, 2026LOSCALZO JOSEPHdirectorSell59,508$74.90
May 6, 2026LOSCALZO JOSEPHdirectorOption10,968$38.06
May 5, 2026KLEIN JOSEPH IIIdirectorOption10,111$47.11
May 5, 2026KLEIN JOSEPH IIIdirectorSell8,680$73.35
May 5, 2026KLEIN JOSEPH IIIdirectorSell1,431$74.45
Apr 30, 2026Baroldi Josephofficer: EVP, Chief Business OfficerSell1,626$71.79
Apr 17, 2026Birchler Brianofficer: EVP, Corp and Development OpsSell973$75.04
Apr 17, 2026PARSHALL B LYNNEdirectorSell534$76.97
Apr 17, 2026Birchler Brianofficer: EVP, Corp and Development OpsOption1,875—
Apr 17, 2026Baroldi Josephofficer: EVP, Chief Business OfficerSell5,619$74.56
Apr 17, 2026Jenne Kyleofficer: EVP, Chf GL Pdt Str OfcrOption12,226—
Apr 17, 2026PARSHALL B LYNNEdirectorSell4,466$76.19
Apr 17, 2026Baroldi Josephofficer: EVP, Chief Business OfficerOption10,837—
Apr 17, 2026Jenne Kyleofficer: EVP, Chf GL Pdt Str OfcrSell4,902$75.17
Apr 2, 2026KLEIN JOSEPH IIIdirectorSell20,105$75.50
Apr 2, 2026Devers Shannon L.officer: EVP, Chief Human Resources OfcSell6,193$74.05
Apr 2, 2026KLEIN JOSEPH IIIdirectorOption12,000$38.06
Apr 2, 2026KLEIN JOSEPH IIIdirectorSell2,216$75.95
Apr 2, 2026KLEIN JOSEPH IIIdirectorOption10,321$41.08
Mar 23, 2026Schneider Eugeneofficer: EVP, Chf Clinical Develop OfcrSell5,812$70.97

Source: IONS SEC Form 4 filings, latest Jun 3, 2026. For informational purposes only — not investment advice.

Institutional activity (13F)

How institutions changed their IONS positions over the last 6 months (SEC Form 13F).

Increased
374
New positions
169
Reduced
297
Sold out
111
Largest moves
InstitutionActionSharesFiled
FMR LLCIncreased24.6MMay 15, 2026
FMR LLCIncreased24.1MFeb 17, 2026
CAPITAL WORLD INVESTORSIncreased21.2MMay 13, 2026
CAPITAL WORLD INVESTORSIncreased18.0MFeb 11, 2026
VANGUARD GROUP INCReduced16.4MJan 29, 2026
BLACKROCK, INC.Increased10.6MFeb 12, 2026
BLACKROCK, INC.Reduced10.4MMay 13, 2026
T. ROWE PRICE INVESTMENT MANAGEMENT, INC.Reduced9.1MFeb 19, 2026
VANGUARD PORTFOLIO MANAGEMENT LLCNew Position7.8MMay 8, 2026
VANGUARD CAPITAL MANAGEMENT LLCNew Position7.1MMay 15, 2026
WELLINGTON MANAGEMENT GROUP LLPIncreased6.4MMay 15, 2026
WELLINGTON MANAGEMENT GROUP LLPReduced6.3MFeb 17, 2026
T. ROWE PRICE INVESTMENT MANAGEMENT, INC.Reduced6.2MMay 15, 2026
TWO SIGMA INVESTMENTS, LPIncreased5.9MMay 15, 2026
BELLEVUE GROUP AGReduced4.8MFeb 17, 2026

Source: SEC Form 13F filings. For informational purposes only — not investment advice.

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